Origins of the word "Liposome"

The word “Liposome” is a combined term of two Greek words “lipos” and “soma”, meaning fat and body respectively. Liposomes are small spherical particles composed mainly from a string of small bodies of fat known as lipid vesicles which made up of phospholipid and water.

What are Phospholipids?

Phospholipids have a structure of a hydrophilic (water soluble) head and a hydrophobic (water repelling) tail. 

When these phospholipids are hydrated, the hydrophilic heads are attracted to the aqueous medium. Simultaneously, the hydrophobic tails mutually attract to each other and repelling to the aqueous medium. This process forms the bilayer membrane structure with one layer of the head groups faces the exterior of the cell, whereas another layer of polar head groups faces the internal cellular environment. At the end, the bilayer membrane seals off to form a sphere shape liposome.

What so special about the structure of liposome?

This unique structure of liposome offers the capability to encapsulate active ingredients within the center core of the double layer membrane. This helps protect the active ingredient against the hostile environment of the digestive system, allowing the active ingredient efficiently delivered to the cells and tissues. In result, this helps optimizing the absorption rate of the active ingredients and maintain its bioavailability.